Antineoplastic USP Grade APIs Daunorubicin Hydrochloride with CAS 23541-50-6

Antineoplastic USP Grade APIs Daunorubicin Hydrochloride with CAS: 23541-50-6

English name:Daunorubicin Hydrochloride

Specification: 99%

CAS NO.:23541-50-6

Appearance: Red to Orange Red crystalline powder

This product is the first generation of anthracycline antitumor Antibiotics. The mechanism resembles doxorubicin. As a cycle non-specific chemotherapy drugs, daunorubicin spectrum anti-tumor doxorubicin far more narrow, for Solid Tumors great as doxorubicin and epirubicin.

Daunorubicin is a clinical first-line anti-cancer drug, is widely used in the clinical treatment of cancer. However, in human liver widespread carbonyl reductase 1 daunorubicin can be converted into a new alcohol metabolite daunorubicin alcohol. This new generation of alcohol metabolites not only lower than the anti-tumor activity of daunorubicin, but also toxic to the heart, resulting in myocardial cell injury.

The metabolic characteristics of daunorubicin greatly limits its clinical application. If we can find a carbonyl reductase inhibitors, not only can improve the clinical efficacy of daunorubicin and other anthracycline anticancer drugs, but also can reduce the toxic side effects of daunorubicin.

Certificate Of Analysis
ITEM		SPECEFICATIONS	RESULTS
Appearance	Description	Red to Orange Red crystalline powder	Conforms
Identification	IR Spectrum	Conforms to reference standard	Conforms
	HPLC	Conforms to reference standard	Conforms
pH		4.5~6.5	5.2
Heavy metals		20 ppm max	Conforms
Water		2.0%max	0.99%
Related substance	Any other impurity	1.5% max	0.84%
	Total impurities	3.0% max	1.66%
Solvent residue	Ethanol	0.5% max	0.15%
	Butanol	1.0% max	0.22%
	Chloroform	0.006% max	Not detected
	Acetone	0.5% max	Not detected
	Carbinol	0.5% max	Not detected
Assay (by HPLC)		90~102% calculated on anhydrous and solvent-free basis	94.77%
Conclusion		Comply with in-house standard