CAS NO 2392-39-4/C22H29FO5 Sodium phosphate dexamethasone

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dexamethasone sodium phosphate raw material
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1.Dexamethasone sodium phosphate is a synthetic adrenocortical steroid used to treat inflammatory and autoimmune conditions;
2.Dexamethasone sodium phosphate is used to treat conditions such as skin conditions, ulcerative colitis, psoriasis, arthritis, allergic disorders and breathing related problems;
3.Dexamethasone sodium phosphate is given to cancer patients undergoing chemotherapy, to prevent certain side-effects:
4.Dexamethasone sodium phosphate is also used in the treatment of high altitude cerebral edema.

1. Chemical Data
CAS No: 2392-39-4
Synonyms: Dexamethasone 21-phosphate disodium salt;
Dexamethasone Phosphate Sodium;
Dexamethasone 21-(disodium phosphate);
Dexamethasone Sodium Phosphate;
Dexamethasone Phosphate Disodium
Molecular Formular: C22H29FO5
Molecula Weight: 392.4611
EINECS NO: 219-243-0
Appearance: White or almost white powder
Uses: Adrenal cortical hormones drugs with anti-inflammatory,antivirus,allergy effect

Sodium phosphate dexamethasone
Chemical Data	CAS No	2392-39-4
	Synonyms	Dexamethasone 21-phosphate disodium salt; Dexamethasone Phosphate Sodium; Dexamethasone 21-(disodium phosphate); Dexamethasone Sodium Phosphate; Dexamethasone Phosphate Disodium
	Molecular Formular	C22H29FO5
	Molecula Weight	392.4611
	EINECS NO	219-243-0
	Appearance	White or almost white powder
	Packing	25kg carton
	Uses	Adrenal cortical hormones drugs with anti-inflammatory,antivirus,allergy effect
	Storage	Keep in sealed and damp proof place.
Chemical Specification	Items		BP2007	USP37
	Apperance		White or almost white powder	White or slight yellow Crystalline powder
	Identification		B.C	A.B
	Solution S.		1.0g/20ml water	==
	Appearance of solution		Clear and not more intensely colored than reference solution B7	===
	PH		7.5-9.5	7.5-10.5
	Optical rotation		75°- 83°	74°- 82°
	Related substances		Total impurities:1.0% max Any impurities:0.5% max	Total impurities:2.0% max Any impurities:1.0% max
	Inorganic phosphate		1.0% max	1.0% max
	Limit of free dexamethasone		---	1.0% max
	Ethanol		3.0% max	8.0% max
	Ethanol and water		13% max	16% max
	Assay		97-103%	97-102%
	Residual solvent		Acetone:5000ppm max Methano:l 3000ppm max	Acetone:5000ppm max Methano:l 3000ppm max
	Batch size		100kg
	Quantity		30kg
Conclusion	Conform to BP2007 and USP37

Packing :25kg carton

Usage:

Adrenocorticotropic Hormone drugs, anti-inflammatory, anti-allergic and anti-drug more effective than prednisone, and promoting the removal of potassium sodium retention is very light, intramuscular or intravenous pituitary - adrenal strong inhibition:

1. Anti-inflammatory effects: The product can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation in sites of inflammation and inhibition of phagocytosis, lysosomal enzyme release and synthesis and release of inflammatory chemical mediators. Can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.

2. Immunosuppressive effect: preventing or inhibiting cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response. Can reduce immune complexes through the basement membrane, and can reduce the concentration of ingredients complement and immunoglobulins.

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